Subthreshold depression in the elderly
Conditions
Interventions
Subthreshold depression in the elderly:None
Healthy control group:None
Sponsors
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: Subthreshold Depression (StD) Group: 1.Aged 60 years or older; 2.Initially screened using the GDS-30 (score > 10), followed by a clinical interview conducted by a psychiatrist based on DSM-5 criteria, coordinated by the researcher who is responsible for participant appointment, data organization, and result summarization. In case of diagnostic disagreement, the research team will reach a consensus through discussion. Individuals meeting all of the following criteria are included: presence of = 2 depressive symptoms (including at least one core symptom: depressed mood or loss of interest/pleasure), symptom duration of at least two weeks, accompanied by some degree of social functional impairment, but not meeting the full diagnostic criteria for any depressive disorder (including mild, moderate, or major depressive episode, or dysthymia) according to DSM-5; 3.No communication barriers, or able to communicate after visual/auditory correction; 4.Possess basic smartphone operation skills, or able to independently read and click on electronic questionnaires after training; 5.Voluntarily participate in this study, sign written informed consent, and commit to completing 14 consecutive days of intensive longitudinal ecological momentary assessment (EMA) tasks. Healthy Control (HC) Group: 1.GDS-30 score <= 10, with no diagnosis of depression; 2.Other inclusion criteria are the same as those for the StD group; 3.Matched with the StD group for sex, age, and years of education.
Exclusion criteria
Exclusion criteria: 1.A history of severe organic brain disease (e.g., massive cerebral infarction, cerebral hemorrhage, brain tumor, etc.) or other progressive neurodegenerative diseases (e.g., Parkinson's disease, Alzheimer's disease, etc.) based on self-reported medical history or community medical records; 2.Suffering from severe and unstable physical illnesses (e.g., severe heart failure, severe asthma) or endocrine system diseases that may affect mood (e.g., thyroid dysfunction), making it impossible to complete the study procedures as required; 3.Cognitive impairment indicated by the Mini-Mental State Examination (MMSE) (cutoffs based on education level: <=17 for illiterate, <= 20 for primary school education, <= 24 for middle school education or above), to exclude interference with questionnaire comprehension due to cognitive impairment; 4.Previous or current diagnosis of a definite mental disorder (e.g., major depressive disorder, bipolar disorder, schizophrenia, etc.); 5.History of antidepressant or antipsychotic medication use, or severe alcohol/substance abuse within the past two months; 6.Severe visual, auditory, or upper limb motor impairments (e.g., severe tremor) that, even with age-friendly assistive devices (e.g., enlarged screen fonts), still prevent independent completion of mobile-based diary questionnaires; 7.Currently participating in other clinical trials or psychological intervention studies (to avoid confounding effects of intervention).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Emotional Variability (iSD);Emotional Inertia (AR-1);Daily Perceived Stress;Daily Social Support; | — |
Secondary
| Measure | Time frame |
|---|---|
| Depressive Symptoms (GDS-30);Cognitive Function (MMSE);Sleep Quality; | — |
Countries
China
Contacts
Public ContactWu Dongmei
Sichuan Provincial People's Hospital
Outcome results
None listed