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Effects of Modified Mandibular Advancement Device on Blood Pressure and Inflammatory Factors in Patients with Refractory Hypertension Complicated with Obstructive Sleep Apnea Hypopnea Syndrome

Effects of Modified Mandibular Advancement Device on Blood Pressure and Inflammatory Factors in Patients with Refractory Hypertension Complicated with Obstructive Sleep Apnea Hypopnea Syndrome

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600126299
Enrollment
Unknown
Registered
2026-06-05
Start date
2026-06-07
Completion date
Unknown
Last updated
2026-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Resistant Hypertension?Obstructive Sleep Apnea Hypopnea Syndrome

Interventions

control group:Oral antihypertensive drug treatment
Treatment group, control group:Mandibular advancement appliance therapy

Sponsors

The First Hospital of Nanchang
Lead Sponsor

Eligibility

Sex/Gender
All
Age
19 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients with refractory hypertension complicated with OSAHS;

Exclusion criteria

Exclusion criteria: People with severe dysfunction of the heart, liver and kidney, serious mental illnesses, as well as minors, pregnant women and breastfeeding women;

Design outcomes

Primary

MeasureTime frame
AHI;blood pressure;

Secondary

MeasureTime frame
Upper airway morphology;

Countries

China

Contacts

Public ContactRao Kunrui

The First Hospital of Nanchang

raokunrui17@163.com+86 791 8886 2237

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 11, 2026