Non-small cell lung cancer brain metastasis
Conditions
Interventions
Case group:NA
Sponsors
Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years, any gender; 2. Histologically or cytologically confirmed NSCLC, with brain metastases confirmed by contrast-enhanced MRI of the head; 3. According to real-world treatment plans, planned to receive radiotherapy combined with PD-1/PD-L1 inhibitor therapy; 4. Driver gene negative, or positive but previous targeted therapy failed; 5. ECOG performance status score 0–2, expected survival >=3 months; 6. Voluntarily signs the informed consent form, agreeing to cooperate with blood/image collection and follow-up.
Exclusion criteria
Exclusion criteria: 1. History of whole-brain radiotherapy, stereotactic radiotherapy for brain metastases, or brain surgery; 2. Contraindications to MRI or inability to tolerate gadolinium contrast agents (e.g. severe hepatic or renal impairment); 3. Active autoimmune disease requiring systemic treatment, or long-term use of high-dose immunosuppressants; 4. Pregnant or breastfeeding women; 5. Other circumstances where the investigator determines that there are serious complications or that the patient is unsuitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intracranial Progression-Free Survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intracranial Objective Response Rate;Overall Survival; | — |
Countries
China
Contacts
Public ContactRongrong Zhou
Xiangya Hospital of Central South University
Outcome results
None listed