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A Study on Conversion Therapy for Intermediate-to-Advanced Hepatocellular Carcinoma Using Kang’ai Combined with HAIC/TACE and Targeted Immunotherapy

A Study on Conversion Therapy for Intermediate-to-Advanced Hepatocellular Carcinoma Using Kang’ai Combined with HAIC/TACE and Targeted Immunotherapy

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600126254
Enrollment
Unknown
Registered
2026-06-05
Start date
2026-06-10
Completion date
Unknown
Last updated
2026-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intermediate to advanced hepatocellular carcinoma

Interventions

Observation group:None

Sponsors

The First Hospital of Nanchang
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age >= 18 years; 2. Generally in good condition, ECOG PS 0-1; 3. Clinically or pathologically diagnosed with hepatocellular carcinoma according to the "Guidelines for the Diagnosis and Treatment of Primary Liver Cancer (2022 Edition)"; 4. At least one measurable lesion on imaging; 5. Liver function Child-Pugh class A or B; 6. No significant abnormalities in peripheral blood white blood cells and platelets in laboratory tests; 7. Informed consent from the patient.

Exclusion criteria

Exclusion criteria: 1. Combined severe dysfunction of other major organs such as heart, lungs, brain, or kidneys, accompanied by severe infection or systemic disease; 2. Liver function Child-Pugh class C, or ECOG PS score >=2; 3. Presence of other malignant tumors; 4. History of allergy to related drugs; 5. Contraindications to TACE or HAIC; 6. Incomplete follow-up data.

Design outcomes

Primary

MeasureTime frame
Antitumor Efficacy and Adverse Reactions;

Countries

China

Contacts

Public ContactZeng Guangzheng

The First Hospital of Nanchang

1064388254@qq.com+86 791 8735 0300

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 11, 2026