Perioperative Period of Liver Transplantation of liver failure
Conditions
Interventions
Regular multiple artificial liver treatment group:Once every other day in the first week of enrollment, three times, once every 2-3 days in the second week, two times, and once a week from then to bef
On demand artificial liver treatment group:Once every week after enrollment until before liver transplantation
Sponsors
Fudan University Huashan Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients who are diagnosed with liver failure and are in the perioperative period of liver transplantation according to the diagnostic and therapeutic guidelines for liver failure (2024 Edition): severe liver injury caused by various reasons, resulting in serious impairment or decompensation of synthesis, detoxification, metabolism and biotransformation functions, blood coagulation disorders (INR >= 1.5), elevated total bilirubin (>= 10 mg/dl or >= 171 µ mol/l), with or without hepatic encephalopathy, hepatorenal syndrome, ascites, etc., meet the criteria for liver transplantation after liver transplantation evaluation (rapid progression of hepatic encephalopathy (grade II or above); Hepatorenal syndrome; Severe coagulation dysfunction (persistently elevated INR) or within 4 weeks after liver transplantation. 2. There was no limit on gender, and only adult cases were included, older than 18 years old and younger than or equal to 80 years old; 3. The patient and his family members understood and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with active bleeding and severe cardiac dysfunction or hemodynamic instability; 2. Participate in other clinical experiments at the same time; 3. Patients with severe allergy to blood products; 4. Female patients who are pregnant, lactating or planning pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| survival rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of multiple organ failure;Early allograft dysfunction;mechanical ventilation duration;Duration of vasoactive drug use;ICU stay;Postoperative complications; | — |
Countries
China
Contacts
Public ContactZhu Xinfang
Fudan University Huashan Hospital
Outcome results
None listed