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Research on the Effect of Photothermal arginine-engineered Bacteria in Targeted Therapy for Oral Squamous cell Carcinoma and Its Mechanism of Promoting Immune Reprogramming in the Tumor Microenvironment

Research on the Effect of Photothermal arginine-engineered Bacteria in Targeted Therapy for Oral Squamous cell Carcinoma and Its Mechanism of Promoting Immune Reprogramming in the Tumor Microenvironment

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600126238
Enrollment
Unknown
Registered
2026-06-05
Start date
2026-07-01
Completion date
Unknown
Last updated
2026-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

oral squamous cell carcinoma

Interventions

Observation group:None

Sponsors

Peking University Shenzhen Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 70; 2. Suspected of having oral squamous cell carcinoma through clinical and conventional imaging diagnoses and with surgical indications; 3. No history of severe allergies; 4. Voluntarily participated in this study with the consent of their guardian and signed the informed consent form. They were able to be followed up and had good compliance.

Exclusion criteria

Exclusion criteria: 1. Have undergone oral surgery; 2. Received radiotherapy or neoadjuvant chemotherapy for oral squamous cell carcinoma; 3. Allergic to ICG; 4. Participated in clinical trials within three months; 5. Childbearing age who are breastfeeding or pregnant or have not used adequate contraception; 6. Researchers consider it unsuitable to participate in this study.

Design outcomes

Primary

MeasureTime frame
tumor size in tumor-bearing mice;

Countries

China

Contacts

Public ContactChen Rourong

Peking University Shenzhen Hospital

chenrourong@whu.edu.cn+86 755 83923333

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 11, 2026