Parkinson's disease
Conditions
Interventions
External Stimulus Test Group:During the 3-7 day external test period in the same patient, polysomnography (PSG) is used to record local field potentials (LFP) in the frontoparietal cortex and STN duri
High-frequency stimulation group:Both during the day and at night, the subjects received the commonly used high-frequency stimulation (130Hz, 2.0mA, pulse width 60µs, monopolar stimulation), with the
Optimized stimulation group:This group received other optimal stimulation parameters for improving sleep during the night (such as 4Hz, 1.0mA, pulse width 60µs, monopolar stimulation). The stimulation
Sponsors
Beijing Tiantan Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients with Parkinson's disease (PD) who were hospitalized in the Functional Neurosurgery Department of Tian Tan Hospital and underwent DBS surgery according to the diagnostic criteria of the British Brain Bank; 2. With sleep disorders (such as difficulty falling asleep, abnormal movements at night, REM sleep behavior disorder, etc.); 3. Age 50-75 years old, with a disease duration of more than 5 years; 4. H-Y stage >= 2.0, MMSE score >= 24, good patient compliance, and able to cooperate with the requirements of postoperative follow-up; 5. Preoperative sleep assessment (such as PDSS-2, sleep disorder SQ, etc.) shows obvious sleep disorders. 6. Bilateral STN-DBS surgery was performed.
Exclusion criteria
Exclusion criteria: 1. Patients with contraindications for DBS surgery, such as severe cognitive impairment, mental illness, intracranial infection, etc.; 2. Patients with severe mental, cognitive, or psychological disorders who cannot sign the informed consent form or cannot cooperate with the surgery and various tasks; 3. Patients with contraindications for neurosurgery, such as hydrocephalus, brain atrophy, sequelae of cerebrovascular diseases, heart diseases and other cardiovascular and cerebrovascular diseases; 4. Patients with accompanying diseases that seriously affect health, such as tumors, severe abnormalities in liver and kidney functions (indicating values exceeding normal limits by three times); 5. Patients with claustrophobia or implanted objects in the body, which affect MRI scans; 6. Patients who cannot cooperate with postoperative follow-up or data collection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall improvement rate of sleep quality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Symptoms of REM sleep behavior disorder;Pittsburgh Sleep Quality Index;Polysomnogram;Cognitive function;Executive function;Emotional state;Behavioral assessment; | — |
Countries
China
Contacts
Public ContactZhang Jianguo
Beijing Tiantan Hospital
Outcome results
None listed