Infectious disease
Conditions
Interventions
Observation group:None
Sponsors
The First Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age range: 18-75 years old, conscious, normal cognitive function, and voluntarily participating in this study; 2. Meet the diagnostic criteria for infectious diseases (refer to "Infectious Diseases, 9th Edition"); 3. Complete clinical diagnostic data, with no significant changes in diet and medication for at least 1 month, or no prior systematic treatment targeting the specific disease; 4. Accessible relevant biological samples and clinical test data, and consent to participate in follow-up; 5. No history of severe mental illness (such as schizophrenia, acute episodes of bipolar disorder, etc.), able to accurately cooperate with follow-up communication and information entry; 6. The study can obtain residual biological samples after routine clinical tests, including but not limited to: serum, plasma, whole blood, sputum, cerebrospinal fluid, feces, throat swabs, urine, pus, and other body fluid samples, and the samples have not undergone additional artificial processing, retaining the original clinical test characteristics.
Exclusion criteria
Exclusion criteria: 1. Pregnant or breastfeeding women, or women of childbearing age, with a positive result in the screening period for chorionic gonadotropin (HCG) test; 2. Acute myocardial infarction, stroke, severely uncontrolled hypertension (diastolic =120mmHg or systolic =220mmHg), kidney transplant, severe liver disease, alcoholism, mental illness, malignant tumors, or severe infections within the past six months; 3. Specimens that are obviously contaminated, hemolyzed, or damaged due to freezing and thawing during collection, transport, or storage, and cannot meet the testing requirements; 4. Clinical information is severely missing or cannot be matched with medical records; 5. Systematic modified electroconvulsive therapy (MECT), transcranial magnetic stimulation (TMS), or other physical treatments received within 3 months prior to screening; concurrent immunodeficiency diseases (such as HIV infection) or receiving immunosuppressive therapy; 6. Concurrent immunodeficiency diseases: such as human immunodeficiency virus (HIV) infection, congenital immunodeficiency, etc. The infection characteristics and resistance mechanisms in immunocompromised populations are completely different from those in the general population, which may easily introduce research bias.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity and Specificity of Drug Resistance Gene Detection;Pathogen Identification Accuracy;Performance indicators of drug resistance warning model and cross-border transmission warning model (AUC, accuracy, specificity, sensitivity);Achievements in the Construction of the Specialized Database for Infectious Diseases (Data Entries, Sample Coverage, Data Completeness);Diagnostic accuracy rate of infectious diseases; | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement in Clinical Diagnosis and Treatment Efficiency of Infectious Diseases;Improvement degree of infectious disease testing capability in primary medical institutions; | — |
Countries
China
Contacts
Public ContactShan Bin
The First Affiliated Hospital of Kunming Medical University
Outcome results
None listed