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Effect of Preoperative Geriatric Nutritional Risk Index on the ED50, ED95, and Sedative Efficacy of Remimazolam Combined with Remifentanil in Elderly Patients Undergoing Painless Gastrointestinal Endoscopy

Effect of Preoperative Geriatric Nutritional Risk Index on the ED50, ED95, and Sedative Efficacy of Remimazolam Combined with Remifentanil in Elderly Patients Undergoing Painless Gastrointestinal Endoscopy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600126218
Enrollment
Unknown
Registered
2026-06-05
Start date
2026-06-08
Completion date
Unknown
Last updated
2026-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sedation-related responses during painless gastrointestinal endoscopy

Interventions

Low GNRI group (GNRI =98):Remimazolam combined with remifentanil sedation

Sponsors

Wuxi No.2 People’s Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Age >=65 years; 2.Patients scheduled for painless gastroscopy who have passed pre-anesthesia outpatient evaluation; 3.American Society of Anesthesiologists (ASA) physical status I–III; 4.All patients voluntarily sign the written informed consent;

Exclusion criteria

Exclusion criteria: 1.Presence of bradycardia (heart rate 30 kg/cm^2;

Design outcomes

Primary

MeasureTime frame
ED50 of remimazolam;ED95 of remimazolam;—

Secondary

MeasureTime frame
Recovery time;Peripheral oxygen saturation;Onset time;Total dose of remimazolam;Time to first supplemental dose;Hemodynamic variables;Incidence of adverse events;Initial dose of remimazolam;—

Countries

China

Contacts

Public ContactDongxiao Huang

Wuxi No.2 People’s Hospital

hdxss88@sina.com+86 510 9612369

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 11, 2026