Catheter-Related Bladder Discomfort (CRBD)
Conditions
Interventions
Control group:An equal volume of normal saline was administered intravenously 30 minutes before the end of surgery.
Tegileridine group:Tegileridine fumarate 1 mg was administered intravenously 30 minutes before the end of surgery.
Sponsors
Chongqing University Cancer Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Male patients aged 18–80 years; 2.ASA physical status class I–III; 3.Undergoing elective transurethral resection of bladder tumor under general anesthesia; 4.Body mass index (BMI): 18–30 kg/m²; 5.Fully informed of the trial procedure, voluntary participation in the study, and signed informed consent obtained.
Exclusion criteria
Exclusion criteria: 1.Patients with contraindications to general anesthesia or a history of previous anesthetic accidents; 2.Patients with known or suspected allergy or contraindication to any component of the study drug or routine medications specified in the research protocol; 3.History of drug abuse, alcoholism, or drug dependence; 4.Suspected abuse of narcotic analgesics or sedatives; 5.Complicated with craniocerebral injury, intracranial hypertension, stroke, unstable angina pectoris, or myocardial infarction; 6.History of mental disorders, chronic pain or abnormal pain sensation; 7.Past history of psychiatric diseases or preoperative cognitive impairment; 8.Males in the childbearing preparation period; 9.Participation in any clinical drug trial within 30 days prior to screening; 10.Preoperative urinary tract infection accompanied by symptoms such as frequent micturition, urgent micturition and dysuria; 11.Occurrence of severe intraoperative complications such as reflux aspiration and bronchospasm; 12.Any other conditions deemed inappropriate for participation in this trial by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence and severity of Catheter-Related Bladder Discomfort (CRBD); | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of nausea, vomiting, respiratory depression, dizziness and hypotension within 24 hours postoperatively;Pain scores and sedation scores at 0, 1, 6 and 24 hours postoperatively;Use of rescue medications within 24 hours postoperatively;Patient satisfaction at 6 hours postoperatively; | — |
Countries
China
Contacts
Public ContactQianyun Pang
Chongqing University Cancer Hospital
Outcome results
None listed