Depression
Conditions
Interventions
Adolescent Major Depression Disorders with mixed features group:None
Adolescent Major Depression Disorders without mixed features group:None
Sponsors
Affiliated Hospital of North Sichuan Medical College
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: Patient Group 1. Meet the DSM-5 diagnostic criteria for Major Depressive Disorder (MDD), and the current depressive episode has not remitted. 2. Aged 12–18 years; first-episode and treatment-naïve, or having completed a washout period of >=2 weeks (2 weeks for antidepressants, 4 weeks for mood stabilizers). 3. No contraindications to MRI (e.g., claustrophobia, metal implants, cardiac pacemakers); normal or corrected-to-normal vision (>=0.8). 4. Able to cooperate with the study procedures, including remaining supine for =30 minutes to complete the MRI scan and completing eye-movement tasks. 5. No history of physical therapy, and no electroconvulsive therapy or repetitive transcranial magnetic stimulation within 3 months prior to enrollment. 6. Able to understand the study content with the assistance of family members, willing to participate, and provide dual-signature informed consent (guardian and participant). Healthy Control Group 1. No history of psychiatric disorders or serious physical illnesses; never taken psychotropic medications; never received electroconvulsive therapy or repetitive transcranial magnetic stimulation. 2. No family history of psychiatric disorders in first-degree relatives. 3. Matched to the patient group by age, sex, and education (+/-1 year), and no contraindications to MRI. 4. Normal cognitive function (Repeatable Battery for the Assessment of Neuropsychological Status [RBANS] total score >=85). 5. Other criteria identical to criteria 3, 4, and 6 of the patient group (normal vision, able to cooperate with the study, and provision of dual-signature informed consent).
Exclusion criteria
Exclusion criteria: Patient Group 1. Comorbid other psychiatric or neurological disorders (e.g., bipolar disorder, schizophrenia, epilepsy). 2. MDD in clinical remission. 3. Severe physical illnesses (e.g., heart disease, brain tumor). 4. Individuals with claustrophobia. 5. History of substance abuse within the past 6 months. 6. Special populations such as pregnant or breastfeeding women. Healthy Control Group 1. Neurological disorders (e.g., epilepsy, Parkinson’s disease). 2. Severe physical illnesses. 3. Individuals with claustrophobia. 4. Special populations such as pregnant or breastfeeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical outcomes; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neuroimaging;Saccadic Measures;Clinical Scale Assessment;Biological Indicators;Sociological and Behavioral Indicators; | — |
Countries
China
Contacts
Public ContactLuo Jiaming
Affiliated Hospital of North Sichuan Medical College
Outcome results
None listed