Thyroid eye disease (TED/TAO/Graves’ orbitopathy)
Conditions
Interventions
Glucocorticoid-resistant group VS Glucocorticoid-sensitive group:None
Sponsors
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Successfully completed intravenous glucocorticoid therapy in accordance with the EUGOGO guidelines; 2. Compliant with orbital synthetic MRI examinations performed before and after treatment; 3. Aged between 18 and 65 years; 4. Disease duration not exceeding 18 months; 5. Bilateral orbital involvement; 6. No history of treatments other than intravenous glucocorticoid therapy; 7. No other concurrent orbital diseases.
Exclusion criteria
Exclusion criteria: 1. A history of neurological disorders (such as epilepsy, intracranial tumors, etc.) or head trauma; 2. Psychiatric disorders (e.g., autism spectrum disorder); 3. A history of ophthalmic diseases and surgery; 4. MRI contraindications (e.g., metal implants).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in diplopia severity by at least one grade;An increase of at least 8 degrees in the range of ocular movement in any direction;A reduction of at least 2 points in the CAS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Reduction in eyelid retraction by at least 2 mm;Reduction in proptosis by at least 2 mm;A reduction of 1 point in the CAS score;The degree of diplopia improvement was less than one grade;Reduction in the extent of soft tissue involvement;Visual acuity improved by at least 1 unit; | — |
Countries
China
Contacts
Public ContactMengda Jiang
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Outcome results
None listed