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ZFP36 promotes mitautophagy through DUSP1/EGR1 pathway and regulates bone lipid balance in bone marrow mesenchymal stem cells to alleviate osteoporosis

ZFP36 promotes mitautophagy through DUSP1/EGR1 pathway and regulates bone lipid balance in bone marrow mesenchymal stem cells to alleviate osteoporosis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600126188
Enrollment
Unknown
Registered
2026-06-04
Start date
2026-07-01
Completion date
Unknown
Last updated
2026-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoporosis

Interventions

Control group:none

Sponsors

Ningbo Medical Centre Lihuili Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1.Clinical patients who have undergone elective hip or knee joint replacement surgery or have visited the orthopedics department of Li Huili Hospital due to traumatic fractures and have agreed to undergo surgery are eligible, regardless of age, gender or weight.

Exclusion criteria

Exclusion criteria: 1.Patients taking bone health-related medications, as well as those with bone or muscle tissue lesions or severe infections.

Design outcomes

Primary

MeasureTime frame
ZFP36 expression;Expression of key genes involved in mitochondrial autophagy;Regulation of gene expression related to the regulatory pathway;—

Countries

China

Contacts

Public ContactLi Xufeng

Ningbo Medical Centre Lihuili Hospital

lhllixufeng@nbu.edu.cn+86 574 87018701

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 11, 2026