Septic shock
Conditions
Interventions
Control group:Conventional therapy of septic shock plus continuous veno-venous hemofiltration
HA380 Group:Conventional therapy of septic shock +continuous veno-venous hemofiltration+HA380 hemoperfusion
Sponsors
Shandong Provincial Hospital Affiliated to Shandong First Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients with refractory septic shock and acute kidney injury requiring renal replacement therapy within 24 hours of septic shock onset; 2. Age >=18 years; 3. Serum IL-6 >=300 pg/mL; 4. Weight >=40 kg.
Exclusion criteria
Exclusion criteria: 1.Patients with severe chronic organ failure, such as chronic heart failure (NYHA class IV), chronic liver failure (Child-Pugh class C), chronic renal failure (eGFR<15ml/min/1.73m2); 2.Patients with an expected survival time = 24 hours; 3.Patients who need to undergo plasma exchange, double plasma exchange or double plasma molecular adsorption system treatment or other blood purification treatment; 4.Patients with other types of shock at the same time, such as cardiogenic shock, obstructive shock and hypovolemic shock; 5.Patients who received hemadsorption, hemofiltration or other blood purification treatments within 3 days before enrollment; 6.Hemadsorption therapy cannot be initiated: patients with platelet count < 20*109/L or those with contraindications to anticoagulation; 7.Pregnancy or lactation; 8.Acquired immune deficiency syndrome and human immunodeficiency virus carriers; 9.Treating team deems enrolment in the study is not in the best interest of the patient.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to shock reversal ; | — |
Secondary
| Measure | Time frame |
|---|---|
| vasopressor dependency index;Cytokines;28-day all-cause mortality; | — |
Countries
China
Contacts
Public ContactJinjiao Jiang
Shandong Provincial Hospital Affiliated to Shandong First Medical University
Outcome results
None listed