Patients with persistent auditory hallucinations (total score of the Auditory Hallucination Rating Scale (AHRS) > 18).
Conditions
Interventions
TPJ-tTIS intervention group (A group):Transcranial time-interference stimulation (tTIS) targeting the temporoparietal junction (TPJ), for 10 sessions
vHPC-tTIS intervention group (B group):Transcranial time-interference stimulation (tTIS) targeting the ventral hippocampus (vHPC), for 10 sessions
Sham stimulation intervention group (C group):Sham stimulation intervention, for 10 sessions
Sponsors
Suzhou Guangji Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for schizophrenia according to DSM-5; 2. Aged 18–55 years; 3. Have persistent auditory hallucinations (total score of the Auditory Hallucination Rating Scale (AHRS) > 18); 4. Right-handed, with normal hearing, vision or corrected vision; 5. Written informed consent obtained from patients and their families.
Exclusion criteria
Exclusion criteria: 1. Patients with organic brain diseases, psychoactive substance or alcohol dependence, epilepsy, or intellectual disability were excluded; 2. Patients with severe or unstable physical diseases, or clinically significant abnormal laboratory results judged by the researchers to affect subject safety were excluded; 3. Patients with contraindications to tTIS: intracranial metallic foreign bodies, cochlear implants, or intracranial hypertension; 4. Patients who had received ECT within 6 months; 5. Pregnant or lactating women, and women of childbearing age with a positive urine HCG test during the screening period; 6. Patients with obvious negative, impulsive, or disorganized behaviors who cannot cooperate with the examination; 7. Other conditions considered unsuitable for participation in this clinical trial by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Auditory Hallucination Rating Scale (AHRS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Positive and Negative Symptom Scale (PANSS);Clinical General Impression Scale (CGI);Functional magnetic resonance detection;Electroencephalogram detection;Calgary Schizophrenia and Depression Scale (CDSS);Simpson-Angus Scale (SAS); | — |
Countries
China
Contacts
Public ContactGan Hong
Suzhou Guangji Hospital
Outcome results
None listed