Post-stroke diaphragmatic dysfunction
Conditions
Interventions
Group A (rTMS stimulation plus conventional rehabilitation training) :Repetitive transcranial magnetic stimulation(rTMS)
Group B (conventional rehabilitation training plus sham stimulation):Conventional rehabilitation training
Sponsors
The Second Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. No gender restriction, age 18-75 years; 2. First-ever supratentorial stroke patients, within 2 weeks to 6 months of onset; 3. Presence of diaphragm dysfunction (diaphragm thickening fraction less than 20%, diaphragm thickening fraction = (end-inspiratory diaphragm thickness at rest - end-expiratory diaphragm thickness at rest) ÷ end-expiratory diaphragm thickness at rest × 100%); 4. Conscious and alert: (1) MMSE >= 21, assess diaphragm thickening fraction, diaphragm excursion, measure serum BDNF concentration, MIP, MEP, FVC, FEV1; (2) MMSE < 21, assess diaphragm thickening fraction, diaphragm excursion, measure serum BDNF concentration.
Exclusion criteria
Exclusion criteria: 1. Patients with respiratory system diseases such as chronic obstructive pulmonary disease, pulmonary tuberculosis, and lung cancer; 2. Patients whose condition has worsened and vital signs are unstable; 3. Patients with cerebellar and brainstem stroke; 4. Patients with comorbid myasthenia gravis or phrenic nerve paralysis; 5. Patients with severe impairment of important organ functions or critical illness; 6. Patients with contraindications to TMS treatment, such as implanted cardiac pacemakers, epilepsy, or cranial defects on the affected side.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diaphragmatic thickening fraction;BDNF gene polymorphism; | — |
Secondary
| Measure | Time frame |
|---|---|
| Diaphragmatic excursion;Maximal Inspiratory Pressure;Maximal Expiratory Pressure;forced vital capacity;Serum BDNF concentration; | — |
Countries
China
Contacts
Public ContactWenli Wang
The Second Affiliated Hospital of Kunming Medical University
Outcome results
None listed