Aortic Diseases
Conditions
Interventions
Observation group:None
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1)Age >=18 years; (2)Definite diagnosis of aortic disease by computed tomography angiography (CTA) or intraoperative findings; (3)Availability of baseline clinical data, imaging data, and essential laboratory indicators; (4)For participants enrolled in the prospective cohort: ability to understand the study procedures, provide written informed consent, and agree to follow-up; (5)For participants enrolled in the surgical specimen subcohort: in addition to meeting the above inclusion criteria, patients must undergo aortic-related surgery and have eligible intraoperative specimens available for collection.
Exclusion criteria
Exclusion criteria: (1)Definite hereditary aortic disease; (2)Infectious, traumatic, iatrogenic, or inflammatory vasculitis-related aortic lesions; (3)Presence of active malignancy, active infection, severe immune system disease, or long-term systemic immunosuppressive therapy; (4)Severe missingness of clinical data; (5)For participants enrolled in the prospective cohort: anticipated inability to complete follow-up or extremely poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Major adverse aortic events; | — |
Secondary
| Measure | Time frame |
|---|---|
| All-cause mortality;Aortic-related mortality;Aortic-related reintervention;Radiological progression of aortic disease;Perioperative complications;Length of ICU stay;Duration of mechanical ventilation;Total length of hospital stay;Imaging features of periaortic adipose tissue;Obesity- and metabolism-related biochemical parameters;Aortic morphological parameters;Circulating inflammatory and metabolic biomarkers;Histopathological and vascular remodeling markers in aortic tissue;Alterations in the periaortic adipose tissue microenvironment;Aortic rupture; | — |
Countries
China
Contacts
Public ContactJia Hu
West China Hospital, Sichuan University
Outcome results
None listed