Learning Disabilities
Conditions
Interventions
Experimental group:The concentration of inhaled sevoflurane is 0.4-0.6 MAC, with an oxygen concentration of 50%, and the treatment duration is 2 hours.
Sponsors
Guangzhou Medical University Affiliated Women and Children's Medical Center
Eligibility
Sex/Gender
All
Age
3 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for specific learning disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V). 2. Aged between 3 and 18 years (inclusive), right-handed, with no gender restriction. 3. Able to complete all assessments. 4. The subject's parent or legal guardian has adequate reading and comprehension skills to cooperate in completing the relevant assessment scales and follow-up visits. 5. The subject, parent, or legal guardian voluntarily participate in this study after signing written informed consent.
Exclusion criteria
Exclusion criteria: 1. Presence of other neurodevelopmental disorders besides specific learning disorder (e.g., intellectual disability, communication disorder, autism spectrum disorder, attention-deficit/hyperactivity disorder, motor disorder, tic disorder, etc.). 2. Presence of serious physical illnesses or other systemic diseases (e.g., history of renal, hepatic, endocrine, or immune disorders, etc.). 3. Presence of metabolic disorders, neoplasms, infections, or organic neurological diseases. 4. Serum potassium or magnesium levels outside the normal range. 5. History of neuroleptic malignant syndrome or tardive dyskinesia. 6. Participation in another study within 30 days prior to the start of the current study and/or during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Wechsler Intelligence Scale for Children (WISC); | — |
Secondary
| Measure | Time frame |
|---|---|
| Learning Disabilities Screening Scale (PRS);Conners Child Behavior Rating Scale (CRS);Achenbach Child Behavior Checklist (CBCL);Academic Achievement Test (AAT);Learning Skills Diagnostic Test (LSDT);Clinical Global Impression-Severity;Clinical Global Impression-Improvement;Electroencephalogram;Functional Magnetic Resonance Imaging; | — |
Countries
China
Contacts
Public ContactXingrong Song
Guangzhou Medical University Affiliated Women and Children's Medical Center
Outcome results
None listed