Brain injury in premature newborns
Conditions
Interventions
intervention group (conventional care + oral motor intervention):Based on routine care in the NICU, the PIOMI oral motor intervention program was implemented once daily for 12 minutes each time, with
2. Comprehensive gum stimulation and massage: 2 minutes
3. Tongue temperature mild stimulation and activity training: 2 minutes
4. Non-nutritive sucking training (medical pacifier): 6 minutes.
Control group (conventional NICU care):Implement standardized routine care for neonatology, including body position management, warmth care, infection prevention and control, and tube feeding/oral fee
routinely provide pacifiers for basic non-nutritive sucking, without performing systematic perioral massage, gingival stimulation, or tongue intervention. The remaining medical, nursing, and feeding r
Sponsors
Maternity and Child Healthcare Hospital of Lianyungang
Eligibility
Sex/Gender
All
Age
28 Weeks to 34 Weeks
Inclusion criteria
Inclusion criteria: 1. Gestational age at birth: 28-34 weeks; 2. Birth weight <= 1800g; 3. Enrolled within 48 hours after birth, with stable vital signs and circulatory and respiratory functions; 4. The guardians provided informed consent, voluntarily participated in this study, and cooperated with follow-up visits and data collection.
Exclusion criteria
Exclusion criteria: 1. Severe intracranial lesions: Grade III or above intracranial hemorrhage, periventricular leukomalacia, moderate to severe hypoxic ischemic encephalopathy; 2. Severe respiratory disease requiring invasive mechanical ventilation for more than 7 days; 3. Congenital oral and facial malformations, digestive tract malformations, and congenital developmental abnormalities of the central nervous system; 4. Identify genetic and metabolic diseases, severe infections, and multiple organ dysfunction; 5. The mother had a long history of alcohol abuse, drug use, and severe use of psychiatric medications during pregnancy; 6. The guardian refused to cooperate with intervention, image acquisition, and clinical data collection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| deoxyhemoglobin (HbR) concentrations (Bilateral frontal lobe, temporal lobe, parietal lobe, occipital lobe); | — |
Secondary
| Measure | Time frame |
|---|---|
| Oxyhemoglobin (HbO);Feeding outcomes (transition days for full oral feeding, feeding efficiency);Development indicators (daily weight gain rate, head circumference growth rate);Neonatal Behavioral Neurological Assessment; | — |
Countries
China
Contacts
Public ContactDong Li
Maternity and Child Healthcare Hospital of Lianyungang City, Jiangsu Province
Outcome results
None listed