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A multicenter prospective cohort study of I-125 particle brachytherapy with intensity-modulated radiotherapy in the postoperative adjuvant treatment of parotid malignancies

A multicenter prospective cohort study of I-125 particle brachytherapy with intensity-modulated radiotherapy in the postoperative adjuvant treatment of parotid malignancies

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600126145
Enrollment
Unknown
Registered
2026-06-04
Start date
2025-02-24
Completion date
Unknown
Last updated
2026-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

parotid adenocarcinoma

Interventions

Intensity-modulated radiation therapy (IMRT) group:None
I-125 particle brachytherapy group:None

Sponsors

Peking University Hospital of Stomatology
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. The tumor originated in the parotid gland; 2. Pathologic findings of salivary gland carcinoma after surgical treatment; 3. Compliance with the indications for postoperative radiotherapy; 4. Voluntary participation with written informed consent; 5. No serious systemic disease Karnofsky score >= 60;

Exclusion criteria

Exclusion criteria: 1. Previous history of head and neck radiotherapy or chemotherapy for systemic tumors; 2. Those who are currently being treated with other effective programs; 3. History of distant or systemic metastases; 4. History of other head and neck malignancies within 5 years; 5. Clinically significant cardiovascular or cerebrovascular disease, or uncontrolled systemic disease.

Design outcomes

Primary

MeasureTime frame
DFS rate;

Secondary

MeasureTime frame
Overall survival;quality of life;adverse reaction;

Countries

China

Contacts

Public ContactJie Zhang

Peking University Hospital of Stomatology

zhangjie06@126.com+86 10 8219 5246

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 11, 2026