Induction of general anesthesia
Conditions
Interventions
Trial group:The initial dose was set at 0.4 mg/kg. The next dose was determined by the "Biased Coin Design Up-and-Down Sequential Method", with a dose interval of 0.05 mg/kg. If a subject failed to ac
Sponsors
Shanghai Sixth People’s Hospital Afffliated to Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
8 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1. Age 8 to 12 years; 2. ASA physical status I–II; 3. Body mass index (BMI) between the 5th and 85th percentiles.
Exclusion criteria
Exclusion criteria: 1. Hepatic or renal dysfunction, and cardiovascular or endocrine disorders; 2. History of allergy to propofol or remimazolam; 3. Upper respiratory tract infection within the past 4 weeks; 4. History of developmental delay, autism spectrum disorder, or other psychiatric conditions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ED50ED95; | — |
Secondary
| Measure | Time frame |
|---|---|
| Injection pain during the induction period; Hypotension; Respiratory depression;Hypoxia;Choking cough; Laryngeal spasm;Bradycardia; | — |
Countries
China
Contacts
Public ContactYao Jiahui
Shanghai Sixth People’s Hospital Afffliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed