Androgenetic alopecia
Conditions
Interventions
Minoxidil+MN Control Group:Microneedling combined with topical application of 1 ml minoxidil once every two weeks for a total of 12 weeks
rCOL17+MN Group:Microneedling combined with topical application of 1 ml recombinant type XVII collagen once every two weeks for a total of 12 weeks
Sponsors
Department of Dermatology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 50 years, regardless of gender; 2.Meet the clinical diagnostic criteria for androgenetic alopecia, with hair loss severity classified as Norwood/Hamilton grades III to VI for males and Ludwig grades I to II for females; 3.Patients who commit to not using other treatment methods during the study period; 4.Patients who voluntarily participate, comply with the study requirements, understand the treatment plan and follow-up schedule, and have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Women who are pregnant or breastfeeding; 2.Individuals with skin infections, ulcers, or other skin diseases at the site of hair loss that make them unsuitable for treatment; 3.Those who have used medications affecting androgen levels or other topical or systemic drugs that promote hair growth within the 6 months prior to enrollment; 4.Individuals with coagulation disorders; 5.Those with endocrine or metabolic abnormalities, liver or kidney dysfunction, psychiatric disorders, systemic diseases, immune disorders, infectious diseases, etc.; 6.Individuals with hair loss caused by other factors; 7.Those allergic to the study medication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skin barrier parameters:stratum corneum hydration;Skin barrier parameters:transepidermal water loss;Skin barrier parameters:sebum content level;Wound healing area;Wound healing time;Visual analogue scale score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse reaction; | — |
Countries
China
Contacts
Public ContactCui Fan
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
Outcome results
None listed