Constipated patients (having fewer than 3 bowel movements per week and/or Bristol Stool Scale types 1 and 2)
Conditions
Interventions
Placebo group:Administer oral placebo
Probiotics Group:Administer orally a powder containing Pediococcus acidilactici PA53.
Sponsors
General Hospital of Ningxia Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients with constipation (defecation frequency less than 3 times per week and/or Bristol Stool Scale type 1 and 2); 2. Patients who have signed the informed consent form; 3. Patients capable of completing the study in accordance with the trial protocol requirements; 4. Patients (including male patients) have no plans for pregnancy from 14 days prior to screening until 6 months after the trial and voluntarily adopt effective contraceptive measures.
Exclusion criteria
Exclusion criteria: 1. Individuals who have consumed food or medications with functions similar to those being tested within a short period, which may affect the judgment of results; 2. Individuals who alter their dietary patterns during the study period; 3. Individuals with severe allergies or immunodeficiency; 4. Females who are pregnant, breastfeeding, or planning to become pregnant; 5. Individuals with severe diseases of vital organs (e.g., cardiovascular, pulmonary, hepatic, or renal systems), diabetes, severe metabolic disorders (e.g., thyroid diseases), malignant tumors, or severe immune system disorders; 6. Individuals who have used antibiotics within the past two weeks; 7. Individuals with severe psychological or mental disorders; 8. Other individuals deemed unsuitable for participation by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement of constipation symptoms; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life and psychological status;Gastrointestinal functional biochemical markers;Gut hormones;Inflammatory and immune markers;Gut microbiota; | — |
Countries
China
Contacts
Public ContactXia Yuhhan
General Hospital of Ningxia Medical University
Outcome results
None listed