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Value of Necrotic Lymph Node Phenotype Score in Risk Stratification for Distant Metastasis in Stage N3 Nasopharyngeal Carcinoma of the 9th Edition AJCC Staging System

Value of Necrotic Lymph Node Phenotype Score in Risk Stratification for Distant Metastasis in Stage N3 Nasopharyngeal Carcinoma of the 9th Edition AJCC Staging System

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600126129
Enrollment
Unknown
Registered
2026-06-04
Start date
2026-06-04
Completion date
Unknown
Last updated
2026-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lymph node metastasis in nasopharyngeal carcinoma

Interventions

Observation group:None

Sponsors

Sun Yat-Sen Memorial Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
10 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Patients with pathologically confirmed nasopharyngeal carcinoma; 2.Those who received standard radical treatment at our institution and have complete and traceable clinical, treatment, and follow-up data; 3.Having pre-treatment MRI imaging data that can be used for re-evaluation of cervical lymph node necrosis, ENE, and related phenotypes; 4.Capable of being staged according to the AJCC 9th edition based on clinical and imaging data; 5.Having follow-up information available for outcome analysis.

Exclusion criteria

Exclusion criteria: 1.Patients with distant metastasis at initial diagnosis; 2.Those who have previously received anti-tumor therapy for nasopharyngeal carcinoma; 3.Those with concurrent other malignant tumors that may affect the determination of survival outcomes; 4.Those with missing key pre-treatment imaging data, image quality that does not meet the evaluation requirements, or inability to complete the assessment of LNN phenotype; 5.Those with severe missing data on core clinical variables, outcome variables, or follow-up information that cannot be supplemented.

Design outcomes

Primary

MeasureTime frame
Distant metastasis-free survival, DMFS;

Secondary

MeasureTime frame
Overall survival, OS;Disease-free survival, DFS;

Countries

China

Contacts

Public ContactZhou Han

Sun Yat-Sen Memorial Hospital

zhouh1@hku-szh.org+86 20 8133 2536

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 11, 2026