Sepsis
Conditions
Interventions
PCT guidance group:None
Sponsors
Sun Yat-Sen University Sun Yat-Sen Memorial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Meet the Sepsis-3.0 diagnostic criteria, with clear evidence of infection (such as positive blood culture, positive sputum culture, imaging findings suggesting an infectious focus, etc.) and a Sequential Organ Failure Assessment (SOFA) score >=2; 2. Age >=18 years; 3. Duration of antibiotic treatment >=48 hours; 4. Have complete procalcitonin (PCT) test data (number of tests >=3), clinical diagnosis and treatment records, and prognostic outcome information.
Exclusion criteria
Exclusion criteria: 1.Severe immunodeficiency (e.g., long-term use of immunosuppressants, HIV/AIDS), end-stage malignant tumor, or being a pregnant/lactating woman; 2.Organ dysfunction induced mainly by viral/fungal infection or non-infectious inflammation (such as autoimmune diseases, inflammatory response after trauma); 3.Severe lack of key clinical data (such as dynamic PCT monitoring results, prognostic follow-up information); 4.Interruption of follow-up due to transfer to another hospital or voluntary discharge during treatment, resulting in failure to obtain complete prognostic data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day and 90-day mortality rate;Organ dysfunction incidence rate;Reinfection rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| ICU length of stay;Total hospital length of stay;In-hospital mortality rate;ICU mortality rate;Inflammatory cytokine levels;Immune function markers; | — |
Countries
China
Contacts
Public ContactSong Fengqing
Sun Yat-Sen University Sun Yat-Sen Memorial Hospital
Outcome results
None listed