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Effects of Non-Surgical Periodontal Therapy on Intestinal Microecology and Its Functional Products: A Single-Arm Clinical Trial and Fecal Microbiota Transplantation Animal Study

Effects of Non-Surgical Periodontal Therapy on Intestinal Microecology and Its Functional Products: A Single-Arm Clinical Trial and Fecal Microbiota Transplantation Animal Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600126124
Enrollment
Unknown
Registered
2026-06-04
Start date
2026-06-04
Completion date
Unknown
Last updated
2026-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis

Interventions

Sponsors

School and Hospital of Stomatology, Wenzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Age between 20 and 65 years old, with at least 10 remaining teeth; 2. BMI value between 18.5 and 30; 3. In good health, without diabetes or gastrointestinal diseases; 4. Not pregnant or breastfeeding, and currently not a smoker; 5. No periodontal treatment in the past 6 months; 6. No antibiotic use in the past 3 months; 7. The diagnosis criteria for periodontitis simultaneously meet the following 4 conditions: (1) The most severe affected tooth has a clinical attachment loss (CAL) of >= 5mm and a probing depth (PD) of >= 6mm; (2) Radiographic bone loss reaches the middle 1/3 or apical 1/3 of the root; (3) Tooth loss due to periodontitis is <= 4 teeth; (4) There is no occlusal dysfunction, secondary occlusal trauma, occlusal disorder, tooth displacement, etc. that require complex restoration and reconstruction.

Exclusion criteria

Exclusion criteria: 1.Presence of systemic diseases, such as diabetes mellitus and gastrointestinal diseases. 2.Pregnant or lactating women; current smokers. 3.Received periodontal treatment within the past 6 months. 4.Used antibiotics within the past 3 months.

Design outcomes

Primary

MeasureTime frame
Probing Depth (PD);

Countries

China

Contacts

Public ContactDeng Hui

School and Hospital of Stomatology, Wenzhou Medical University

dh0726@163.com+86 577 8806 3030

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 11, 2026