None
Conditions
Interventions
Propofol group: During general anesthesia induction, propofol (2 mg/kg) was administered intravenously at a constant rate over 1 minute by Investigator B.
Remimazolam group:During general anesthesia induction, remimazolam (0.3 mg/kg) was administered intravenously at a constant rate over 1 minute by Investigator B.
Fospropofol disodium:During general anesthesia induction, disodium fospropofol (15 mg/kg) was administered intravenously at a constant rate over 1 minute by Investigator B.
Sponsors
Fuyang People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age = 65 years, with a Body Mass Index (BMI) ranging from 18 to 28 kg/m². 2.American Society of Anesthesiologists (ASA) physical status I–III. 3.Patients undergoing elective surgery with endotracheal intubation under general anesthesia, with an expected duration of less than 3 hours. 4.Patients who understood the study protocol, voluntarily participated, and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients with a known allergy to the anesthetic agents used in this study, or those with a history of severe allergy or a family history of such allergies. 2.Patients with a suspected difficult airway or anticipated difficult intubation. 3.Patients with a history of long-term use of sedatives, analgesics, or non-steroidal anti-inflammatory drugs. 4.Patients with a history of psychiatric disorders, or those with severe dysfunction of the heart, lung, liver, kidney, or brain 5.Patients deemed unsuitable for participation in this study by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the curve of blood pressure and compared to baseline within 10 minutes after induction;Area under the curve of heart rate from baseline to 10 minutes post-induction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sedation/anesthesia after induction (MOAA/S score = 1);Time to BIS = 60 after induction;Quality of recovery;Adverse events; | — |
Countries
China
Contacts
Public ContactDai Chenxu
Fuyang People's Hospital
Outcome results
None listed