Congenital giant naevus
Conditions
Interventions
Case group:NA
Sponsors
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Eligibility
Sex/Gender
All
Age
No minimum to 60 Years
Inclusion criteria
Inclusion criteria: 1.Presence of extensive black discoloration of the skin on the body surface detected since birth, with the largest lesion referred to as the "primary nevus." According to the internationally accepted Krengel classification (Table 2), a diagnosis of large/giant congenital melanocytic nevus (LGCMN) is established when the projected adult size (PAS) of the primary nevus is > 20 cm. 2.Age: 3 months to 60 years. Sex: both males and females. 3.The patient voluntarily participates in this cohort study and provides written informed consent. 4.The patient agrees to provide tissue specimens and peripheral blood for the investigation of genetic correlations and relevant factors underlying the pathogenesis of giant congenital melanocytic nevi. 5.The participant is able to comply with the study procedures and follow-up assessments as required by the protocol.
Exclusion criteria
Exclusion criteria: 1.Poor compliance, or judged by the investigator to be unsuitable for enrollment in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Disease progression rate of giant congenital melanocytic nevi, calculated based on pathological examinations, dermatological assessments, and imaging findings.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in plasma cytokine;Evaluation of recurrence of the giant congenital melanocytic nevus lesion.;Evaluation of the natural history of the disease;Changes in clinical manifestations;The proportion of patients with giant congenital melanocytic nevi achieving stable disease or regression; | — |
Countries
China
Contacts
Public ContactLi Qingfeng
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Outcome results
None listed