Ischemic stroke
Conditions
Interventions
Observation group:none
Sponsors
Affiliated Jinling Hospital, Medical School of Nanjing University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age 18 years or older; 2. Acute ischemic stroke, confirmed by imaging (CTA/MRA/DSA) to have large vessel occlusion (ICA, MCA-M1, ACA-A1, VA, BA, PCA-P1; large vessel defined as visually estimated diameter >=2mm); 3. Time from onset or last known normal to arterial puncture completion <=24 hours; 4. Undergoing endovascular treatment, such as stent retriever thrombectomy, aspiration thrombectomy, or intra-arterial thrombolysis; 5. Pre-stroke modified Rankin Scale (mRS) score <2.
Exclusion criteria
Exclusion criteria: 1. Preoperative imaging confirmed intracranial hemorrhage; 2. Presence of active bleeding or known bleeding tendency; 3. Heart, lung, liver, or kidney failure, or other severe organic diseases; 4. Allergy to contrast agents, nickel-titanium metal, or their alloys; 5. Angiography shows tortuous vascular pathways making it difficult to reach the target position or retrieve the instruments; 6. Loss of medical records and imaging data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 90-day mRS score of 0-2; | — |
Secondary
| Measure | Time frame |
|---|---|
| 90-day mRS score of 0-1;7-day postoperatively NIHSS score;24-hour postoperatively NIHSS score;90-day postoperatively NIHSS score;change in NIHSS score at 90 days postoperatively;Early neurological improvement (=4 reduction in NIHSS score at 24 hours postoperatively);Early neurological deterioration (increase in NIHSS score =4 at 24 hours postoperatively);Delayed neurological improvement (>=4 reduction in NIHSS score at 7 days postoperatively);malignant cerebral edema;intracranial haemorrhage;Symptomatic intracranial haemorrhage; | — |
Countries
China
Contacts
Public ContactWusheng Zhu
Affiliated Jinling Hospital, Medical School of Nanjing University
Outcome results
None listed