Postoperative cognitive dysfunction
Conditions
Interventions
dexmedetomidine -Esketamine group:None
Sponsors
The First Hospital of Shanxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 79 Years
Inclusion criteria
Inclusion criteria: Aged 18–79 years, American Society of Anesthesiologists (ASA) physical status II or III, with a confirmed diagnosis of colorectal cancer, and having provided written informed consent.
Exclusion criteria
Exclusion criteria: Exclusion criteria: history of dementia or psychiatric disorders, central nervous system diseases; severe cardiac, pulmonary, hepatic, or renal dysfunction; uncontrolled hypertension or markedly elevated intraocular pressure; sinus bradycardia or high-degree atrioventricular block; pregnancy or lactation; known allergy to the study anesthetic agents; and history of drug abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of anxiety and depression;opioid consumption.duration of surgery.duration of anesthesia.volume of fluid replacement.estimated blood loss.urine output and other parameters; | — |
Secondary
| Measure | Time frame |
|---|---|
| 3-Minute Diagnostic Interview for Confusion Assessment Method;Incidence of adverse reactions;intraoperative safety indicators;Ricker sedation agitation score, wake-up time; | — |
Countries
China
Contacts
Public ContactZhang Haibin
The First Hospital of Shanxi Medical University
Outcome results
None listed