infertility
Conditions
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for the repetitive study: 1.Women with a history of pregnancy or childbirth (including delivery, induced abortion, medical abortion, and spontaneous abortion, but excluding ectopic pregnancy); 2.Regular menstrual cycles of 28–35 days; 3.Age between 20 and 40 years. Inclusion Criteria for Ultrasound Radiomics Prediction of Endometrial Receptivity: 1. Infertile patients undergoing IVF-ET/ICSI-ET 2. with standard luteal phase long protocol, follicular phase long protocol, GnRH-a prolonged protocol or antagonist protocol, and at least have one high-quality embryo for transfer 3. In frozen-thawed embryo transfer cycle, endometrial preparation include natural cycle, ovulation induction cycle, HRT cycle or GnRHa-HRT cycle, and at least have one high-quality embryo for transfer 4. Age 20-40.
Exclusion criteria
Exclusion criteria: Exclusion Criteria for the repetitive study: 1. Acute stage of pelvic inflammatory disease; 2. Recent or ongoing hormone therapy; 3. History of recurrent spontaneous abortion (=2 pregnancy losses before 28 weeks of gestation with the same partner); 4. Conditions that may affect endometrial receptivity (uterine malformations, intrauterine adhesions, thin endometrium (endometrial thickness <7 mm), endometriosis, adenomyosis, endometrial polyps, submucosal fibroids, hydrosalpinx, etc.); 5. Presence of an intrauterine contraceptive device; 6. Lactation period; 7. Luteinized unruptured follicle syndrome (cycles with luteinization will be cancelled; participants may re-enter the study in the next cycle. Participants will be excluded if luteinization occurs consecutively); 8. Failure to complete two cycles of sample collection (e.g., pregnancy after the first cycle or voluntary withdrawal during the study). Exclusion Criteria for Ultrasound Radiomics Prediction of Endometrial Receptivity: 1. Chromosomal abnormalities in one or both spouses leading to abortion 2. Recurrent miscarriage (=2 pregnancies with the same spouse before 28 weeks) 3. Abnormal uterine cavity (uterine malformation, history of intrauterine adhesions, endometrial polyps, submucosal uterine fibroids, endometrial dysplasia, etc.) 4. Endometriosis disease (including uterine glandular myopathy) 5. Untreated hydrosalpinx 6. Autoimmune diseases and prethrombotic state 7. Failure to complete ultrasound measurement, or incomplete follow-up data in medical records. 8. Failure to complete the embryo transfer in the cycle.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Embryo Implantation Rate;Clinical Pregnancy Rate;Miscarriage Rate;Live Birth Rate; | — |
Countries
China
Contacts
Public ContactYihua Yang
The First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed