drug-induced lung injury
Conditions
Interventions
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18–75 years, ECOG PS 0–2; 2. Patients planned to initiate or currently receiving high-risk pulmonary injury medications (e.g., specific antineoplastic agents, antirheumatic drugs, cardiovascular drugs, etc.); 3. Expected survival >=6 months, with complete baseline clinical assessment data (including HRCT imaging, pulmonary function tests, and laboratory examinations, etc.); 4. Major organ function essentially normal, meeting standard indications for primary disease and high-risk medications.
Exclusion criteria
Exclusion criteria: 1. History of confirmed severe interstitial lung disease, pulmonary fibrosis, or current severe active pulmonary infection; 2. Severe active pulmonary infection within 4 weeks prior to enrollment with incomplete radiological resolution; 3. Severe coagulation disorders or other conditions contraindicating/refusing blood, sputum, or other biological specimen collection; 4. Severe claustrophobia, inability to lie supine, or other objective limitations precluding high-resolution CT (HRCT) examination; 5. Other malignancies besides the primary disease that are not effectively controlled; 6. Female patients during pregnancy or lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulmonary function parameters;Sensitivity;specificity;Area Under the Receiver Operating Characteristic Curve; | — |
Countries
China
Contacts
Public ContactBingwen Zou
West China Hospital of Sichuan University
Outcome results
None listed