prolonged disorders of consciousness
Conditions
Interventions
Experimental Group 1:Received 10 Hz DM-pf single-target true stimulation therapy + conventional rehabilitation therapy
Experimental Group 2:Received 10 Hz DLPFC single-target true stimulation therapy + conventional rehabilitation therapy
Experimental Group 3:Received 10 Hz DM-pf-DLPFC dual-target true stimulation therapy + conventional rehabilitation therapy
Control group:Receive Sham tTIs and conventional rehabilitation treatment
Sponsors
The Third Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
2 Years to 14 Years
Inclusion criteria
Inclusion criteria: 1. Age >2 years and 28 days; 4. Stable vital signs. 5. Written informed consent voluntarily provided by the child’s legal guardians.
Exclusion criteria
Exclusion criteria: 1. Active intracranial hemorrhage or skull defect; 2. Ongoing progression of brain injury; 3. Status epilepticus or seizure occurrence within the past 1 week; 4. Focal brain lesions in the stimulation sites (frontal and parietal regions), as indicated by neuroimaging reports; 5. Persistent severe agitation precluding the placement of tACS, EEG, or fNIRS equipment; 6. Decompressive craniectomy without subsequent cranioplasty; 7. Presence of implanted electronic devices contraindicated for MRI or other imaging modalities; 8. Current or prior participation in other clinical trials that may interfere with the results of this study; 9. Refusal of participation by the patient’s legal guardians.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coma Recovery Scale-Revised; | — |
Secondary
| Measure | Time frame |
|---|---|
| electroencephalogram;Functional Near-Infrared Spectroscopy; | — |
Countries
China
Contacts
Public ContactDengna Zhu
The Third Affiliated Hospital of Zhengzhou University
Outcome results
None listed