Asthma
Conditions
Interventions
Control group:None
Sponsors
The Second Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for the asthma group: 1. Patients meeting the diagnostic criteria for asthma, with the diagnosis based on "Guidelines for the Prevention and Treatment of Bronchial Asthma (2020 Edition)"; 2. Age between 18 and 80 years old; 3. Voluntary participation in this study and signing the informed consent form. Inclusion criteria for the healthy control group: 1. Age between 18 and 80 years old; 2. Voluntary participation in this study and signing the informed consent form.
Exclusion criteria
Exclusion criteria: Exclusion criteria for the asthma group: 1. Patients with acute asthma exacerbation accompanied by respiratory failure and requiring mechanical ventilation; 2.Patients with unconsciousness, dementia, or various mental disorders; 3. Patients with tumors, severe cardiovascular diseases, or severe liver and kidney diseases; 4. Patients who have participated in other clinical studies or are currently involved in other clinical trials. Exclusion criteria for the healthy control group: 1. Patients with a clear diagnosis of respiratory diseases such as asthma, chronic obstructive pulmonary disease, tuberculosis, interstitial lung disease, lung cancer, or bronchiectasis in the past; 2.Patients who have undergone lung lobe resection in the past; 3. Patients who are allergic to bronchodilators or drugs used in bronchial provocation tests; 4. Patients who are currently participating in other clinical studies; 5. Patients seeking treatment for acute respiratory disease attacks at present; 6. Patients who are unable to communicate and cooperate; 7. Patients who are not suitable for pulmonary function testing.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Demographic data ;Symptom characteristics;Allergy/Family history;Pulmonary function indices;Fractional exhaled nitric oxide (FeNO);Genomics: SNPs;Transcriptomics: mRNA/miRNA;Proteomics: Inflammatory cytokines;Metabolomics: Untargeted metabolites;Low-dose CT: Quantitative parameters;Impulse oscillometry (IOS);Exhaled volatile organic compounds (VOCs);Exhaled breath condensate (EBC) analysis;Respiratory sound monitoring; | — |
Countries
China
Contacts
Public ContactChen Yan
The Second Xiangya Hospital of Central South University
Outcome results
None listed