Thrombotic dysfunction of MC refers to the obstruction or complete blockage of infusion through the catheter caused by fibrin sheath, thrombus formation inside the catheter, or thrombus formation at the tip of the catheter, with an incidence rate of up to 27.4%. The main clinical manifestations include the ability to complete catheter flushing or drug infusion despite the catheter being obstructed
Conditions
Interventions
5% sodium bicarbonate solution group:Seal the tube with 2ml of 5% sodium bicarbonate solution under standard positive pressure
Normal saline group:Use 2ml of 0.9% sodium chloride injection and seal the tube under standard positive pressure
heparin saline (10 U/mL) group:Using 10U/ml heparin saline , 2ml tubes were sealed under standard positive pressure
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 years or older but under 80 years old; 2.Due to the need for treatment, a medium to long catheter needs to be inserted, and the duration of intravenous infusion should be = 1 week; 3.The properties of the infusion drugs comply with the indications of MC, including infusion of antibiotics, parenteral nutrition solution, mannitol, blood products, analgesics and other liquids; 4.Clear consciousness, able to communicate normally and sign informed consent forms;
Exclusion criteria
Exclusion criteria: 1.Individuals allergic to physiological saline, 10 U/mL heparin saline, or 5% sodium bicarbonate solution; 2.Individuals with severe coagulation dysfunction (platelet count6s, D-II polymer>5.0 µ g/ml) or those undergoing anticoagulant/antiplatelet therapy (such as warfarin, aspirin); 3.Pregnant or lactating women; 4.Individuals with infections, burns, and neurological disorders in both upper limbs; 5.Severe water sodium retention with edema, oliguria or anuria; 6.There is severe electrolyte imbalance (such as serum sodium160 mmol/L); Serum potassium6.5 mmol/L; Individuals with serum calcium levels3.0 mmol/L; 7.Severe acid-base imbalance (arterial blood pH7.55, bicarbonate (HCO3-)32 mmol/L);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of thrombotic catheter dysfunction;The incidence and formation time of fibrous sheath (FS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Unplanned catheter removal rate;Incidence of catheter-related deep vein thrombosis;MC retention time;Incidence of catheter-related bloodstream infections; | — |
Countries
China
Contacts
Public ContactGu Tingting
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed