oral leukoplakia
Conditions
Interventions
High-concentration topical tretinoin tablets group:High-concentration topical tretinoin tablets
Oral tretinoin tablets group:Oral tretinoin tablets
Low-concentration topical tretinoin tablets group:Low-concentration topical tretinoin tablets
Sponsors
West China Hospital of Stomatology, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Histopathologically confirmed diagnosis of oral leukoplakia; 2.Age 18 years or older; 3.No use of retinoid drugs within the past 3 months; 4.Agreement to participate in the study and provision of signed informed consent;
Exclusion criteria
Exclusion criteria: 1.Pregnant or breastfeeding women, or individuals planning pregnancy within the next 2 years; 2.Patients with hepatic or renal insufficiency or severe systemic diseases; 3.Individuals with a known allergy to retinoid drugs; 4.Histopathological diagnosis of severe dysplasia, carcinoma in situ, or microinvasive carcinoma;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective Response Rate for Oral Leukoplakia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in subjective assessment before and after treatment; | — |
Countries
China
Contacts
Public ContactYu Zhou
West China Hospital of Stomatology, Sichuan University
Outcome results
None listed