Autism
Conditions
Interventions
Control group:The enrolled patients received placebo treatment
Non matching treatment group:Non matching treatment group subjects will receive intestinal microbiota transplantation therapy with non matching donor and recipient populations
Individualized precision matching treatment group:Individualized and precise matching of donor gut microbiota transplantation therapy for enrolled patients
Sponsors
The First People's Hospital of Wuhu
Eligibility
Sex/Gender
All
Age
3 Years to 10 Years
Inclusion criteria
Inclusion criteria: 1. 3-10 years old, male or female not limited; 2. Diagnosed as a child with autism spectrum disorder according to DSM-V; 3. No serious mental disorders; 4. The guardian of the subject agrees to participate in this clinical trial and signs an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Use antibiotics in the past 3 months; 2. Emergency gastrointestinal diseases that rely on tube feeding and require timely medication treatment; 3.Diagnosed with severe malnutrition or excessive weight loss or severe immune deficiency diseases; 4. Has a history of severe allergies; 5. Accompanied by other serious illnesses; 6. Participated in other clinical studies within the previous month prior to screening; 7. Received attenuated live vaccine within 4 weeks prior to screening; 8. Presence of intestinal obstruction and active gastrointestinal bleeding; 9. Suffering from the following heart diseases: NYHA stage III or IV congestive heart failure, history of myocardial infarction or coronary artery bypass grafting (CABG) within =6 months prior to enrollment, clinically significant ventricular arrhythmia, or history of unexplained syncope (excluding cases caused by vasovagal or dehydration), history of severe non-ischemic cardiomyopathy; 10. Other researchers consider it inappropriate to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical manifestations of autism; | — |
Secondary
| Measure | Time frame |
|---|---|
| Gastrointestinal function;Characteristics of gut microbiota; | — |
Countries
China
Contacts
Public ContactGong Weida
The First People's Hospital of Wuhu
Outcome results
None listed