This study investigates the systematic effects of different temperature levels and exposure patterns on human neurophysiological and cognitive functions.
Conditions
Interventions
Acute High-Temperature Group:Multi-Stage High-Temperature Exposure Protocol, then Multi-Stage low-Temperature Exposure Protocol
Chronic High-Temperature Group:Multi-Stage Chronic High-Temperature Exposure Protocol, then Multi-Stage Chronic low-Temperature Exposure Protocol
Acute Low-Temperature Group:Multi-Stage low-Temperature Exposure Protocol, then Multi-Stage High-Temperature Exposure Protocol
Chronic Low-Temperature Group:Multi-Stage Chronic low-Temperature Exposure Protocol, then Multi-Stage Chronic High-Temperature Exposure Protocol
Sponsors
Shanghai Yangzhi rehabilitation hospital
Eligibility
Sex/Gender
All
Age
25 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Aged 25–35 years, both genders eligible; 2. Self-reported good health with no significant cardiovascular, respiratory, neurological, or hematological diseases identified during physical examination; 3. No history of high-temperature work, frequent sauna/sweat bath exposure, or cold-region/low-temperature training within the past month to exclude recent thermal adaptation factors; 4. Intact skin, no severe cold- or heat-related dermatological conditions, normal peripheral blood circulation in extremities, and no diagnosis of Raynaud's phenomenon; 5. Normal visual and auditory function, capable of understanding and cooperating with cognitive tasks, electroencephalography (EEG), functional near-infrared spectroscopy (fNIRS), and peripheral physiological measurements; 6. Willing to complete 2 acute temperature chamber visits, a 1-week washout period, and (if selected) 4 weeks of long-term temperature exposure according to the study schedule; 7. Voluntary participation with signed written informed consent.
Exclusion criteria
Exclusion criteria: 1. History of epilepsy, syncope, unexplained loss of consciousness, or organic central nervous system disorders; 2. Diagnosis of congenital heart disease, confirmed coronary artery disease, arrhythmia, uncontrolled hypertension, or endocrine disorders affecting thermoregulation (e.g., uncontrolled hyperthyroidism/hypothyroidism, diabetic autonomic neuropathy); 3. History of clear intolerance to high or low temperatures (e.g., heat stroke history, severe frostbite history), pronounced Raynaud's phenomenon, or cold-induced urticaria; 4. Fever, acute respiratory infection, acute skin inflammation, or injury at the sensor attachment site within the environmental chamber within the past 4 weeks; 5. Females who are pregnant, breastfeeding, or planning pregnancy in the near future; 6. Presence of claustrophobia, significant anxiety, or inability to tolerate the environmental control chamber; 7. Use of medications affecting thermoregulation, heart rate, and neurophysiological functions within 2 weeks prior to enrollment (specific drug list provided in the main text); 8. Participation in other interventional clinical studies within the past month; 9. Individuals deemed by the investigator as unable to complete all study procedures on schedule or for whom continued participation may pose risks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EEG signal;Reaction time and accuracy during the cognitive task.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood, urine, fecal, and oral/nasal microbiome samples.; | — |
Countries
China
Contacts
Public ContactJin lingjing
Shanghai Yangzhi rehabilitation hospital
Outcome results
None listed