Diabetic cardiomyopathy
Conditions
Interventions
Healthy control group:None
Sponsors
Taizhou People's Hospital
Eligibility
Sex/Gender
All
Age
35 Years to 80 Years
Inclusion criteria
Inclusion criteria: Diabetic Cardiomyopathy group 1. Agree to participate in this study and sign the project informed consent form. 2. Age between 35 and 80 years old. 3. Clinically diagnosed with type 2 diabetes mellitus, with a disease duration of >=5 years. 4. Meet at least one of the following echocardiographic criteria: (1) Interventricular septum thickness: male >=11 mm, female >=10 mm; (2) Left atrial volume index (LAVI) >=34 ml/m^2 or left atrial diameter index >=2.3 cm/m^2; (3) Left ventricular mass index (LVMI): male >=115 g/m^2, female >=95 g/m^2; (4) Diastolic dysfunction: E/A ratio > 2; or E/A ratio 35 mmHg; or E/e' ratio > 10; or isovolumic relaxation time > 100 ms; or E wave deceleration time (DT) > 240 ms; (5) Systolic dysfunction: Left ventricular ejection fraction (LVEF) 125 pg/ml or BNP >40 pg/ml; when BMI > 30 kg/m^2, NT-proBNP >100 pg/ml or BNP >30 pg/ml. Healthy Group: 1. Agree to participate in this study and be able to sign the informed consent form for the project; 2. Age: 35 to 80 years old; 3. No abnormalities were found on the echocardiogram.
Exclusion criteria
Exclusion criteria: 1. Diabetic Cardiomyopathy Group: (1) Presence of coronary heart disease, hypertension, valvular heart disease, and other structural heart diseases; (2) Pregnant or lactating women; (3) History of taking antibiotics, probiotics, or other medications within the past 4 weeks; (4) History of chronic constipation or chronic diarrhea; (5) History of acute gastroenteritis within the past week; (6) Accompanied by severe liver disease, kidney disease, autoimmune disease, infectious disease, or history of malignant tumors; (7) Presence of cognitive or mental disorders; (8) Other systemic diseases that may affect the outcome observation of this project. 2. Healthy Control Group: (1) Pregnant or lactating women; (2) History of taking antibiotics, probiotics, or other medications within the past 4 weeks; (3) History of chronic constipation or chronic diarrhea; (4) History of acute gastroenteritis within the past week; (5) Presence of any underlying diseases such as hypertension, coronary heart disease, diabetes, severe liver disease, kidney disease, autoimmune disease, infectious disease, or malignant tumors; (6) Presence of cognitive or mental disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum metabolites;Protein modification of cardiac tissue; | — |
Countries
China
Contacts
Public ContactLu Chenlin
Taizhou People's Hospital
Outcome results
None listed