None
Conditions
Interventions
Remimazolam group:Intravenous remimazolam besylate was started at a dose of 0.2 mg/ kg
Propofol group:Propofol 1-2 mg/kg was administered by slow intravenous injection
Sponsors
Lu'an People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age over 65 years old, gender not limited; 2. Anesthesia ASA classification I - II; 3. Has a history of hypertension (systolic blood pressure >= 140 mmHg or diastolic blood pressure >= 90 mmHg) before the operation; 4. Body Mass Index (BMI) is normal (18.5 - 30 kg/m^2); 5. Voluntarily participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Allergic to benzodiazepines and anesthetic drugs; 2. Had obvious functional disorders of important organs such as heart, brain, and kidneys before the operation; 3. The preoperative examination results indicated distant metastasis; 4. Had received radiotherapy, chemotherapy, or hormone therapy before the operation; 5. Had long-term use of sedatives and analgesics; 6. Received blood transfusion treatment during the perioperative period; 7. Participated in other studies within the past 3 months; 8. Found distant metastasis during the operation or indicated by the frozen pathological report after the operation; 9. Was transferred to the AICU or ICU non-plannedly after the operation; 10. The patient gave up or was lost to follow-up during the treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hypotension during induction;Stress response indicators ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Man arterial pressure;Heart rate;Cardiac output;Stroke volume;Quality of Recovery;Administration and frequency of supplemental doses of the study drug and/or rescue medication.;Incidence of adverse events during induction; | — |
Countries
China
Contacts
Public ContactFeng Cheng
Wannan Medical College
Outcome results
None listed