None
Conditions
Interventions
Ciprofol 0.2mg/kg group:0.2mg/kg ciprofol combined with low-dose esketamine
Ciprofol 0.3mg/kg group:0.3mg/kg ciprofol combined with low-dose esketamine
Ciprofol 0.4mg/kg group:0.4mg/kg ciprofol combined with low-dose esketamine
Ciprofol 0.5mg/kg group:0.5mg/kg ciprofol combined with low-dose esketamine
Ciprofol 0.6mg/kg group:0.6mg/kg ciprofol combined with low-dose esketamine
Propofol 1.0mg/kg group:1.0mg/kg propofol combined with low-dose esketamine
Propofol 1.4mg/kg group:1.4mg/kg propofol combined with low-dose esketamine
Propofol 1.8mg/kg group:1.8mg/kg propofol combined with low-dose esketamine
Propofol 2.2mg/kg group:2.2mg/kg propofol combined with low-dose esketamine
Propofol 2.6mg/kg group:2.6mg/kg propofol combined with low-dose esketamine
Sponsors
Wenling First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. ASA grade I - III 2. BMI 18 - 28 kg/m² 3. No contraindications for gastroscopy 4. Age 18 - 64 years old
Exclusion criteria
Exclusion criteria: 1. The patient refuses to participate; 2. Allergic to esketamine, propofol or propofol; 3. Patients with severe risks of hypertension, hyperthyroidism, elevated intraocular pressure or intracranial pressure; 4. With a history of severe respiratory and cardiovascular diseases; 5. Currently taking opioid drugs and non-steroidal anti-inflammatory drugs; 6. With neurological disorders or mental disorders or having previous cognitive impairment; 7. Patients with impaired liver and kidney functions; 8. Pregnant or lactating women; 9. ASA classification of grade IV or V.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number of effective and ineffective cases for each dose of ciprofol and propofol;The 50% effective dose (ED50) of ciprofol or propofol; | — |
Secondary
| Measure | Time frame |
|---|---|
| Gastroscopy examination time;The number of cases of artificial assisted breathing;Anesthesia recovery time;Vital signs after anesthesia induction with ciprofol and propofol;Mental symptoms related to esketamine;The number of additional cases of cyclopofol or propofol; | — |
Countries
China
Contacts
Public ContactKang Lin
Wenling First People's Hospital
Outcome results
None listed