Myocardial ischemia-reperfusion, ventricular remodeling, myocardial fibrosis
Conditions
Interventions
The ventricular remodeling group after myocardial ischemia-reperfusion:None
The non-ventricular remodeling group after myocardial ischemia-reperfusion:None
Sponsors
The 960 Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1.The diagnostic criteria for STEMI are met: history of chest pain, characteristic changes on electrocardiogram, and elevation of myocardial necrosis markers. 2.Emergency PCI shows: at least one main coronary artery is occluded, and TIMI grade 0. 3.After emergency PCI: the occluded vessel is re-opened, and blood flow returns to TIMI grade 1, 2, and 3 must all be satisfied simultaneously.
Exclusion criteria
Exclusion criteria: 1.Does not meet the inclusion criteria. 2.Severe cardiovascular or pulmonary diseases, liver or kidney dysfunction, severe infections, malignant tumors. 3.Allergic to the drugs related to the trial, having used drugs that may affect the level of HPSE recently, such as anticoagulants, antiplatelet drugs, anti-inflammatory drugs, etc. 4.Has a recent history of myocardial infarction, has undergone PCI or other cardiac surgeries, and the level of HPSE may be in an abnormal state. 5.Pregnant or lactating women, those with mental or neurological disorders who cannot cooperate to complete the study; incomplete clinical data. Any one of the above conditions will result in exclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heparanase; | — |
Secondary
| Measure | Time frame |
|---|---|
| N-terminal pro-brain natriuretic peptide;Soluble growth-stimulating expression gene 2 protein;Matrix Metallopeptidase-9; | — |
Countries
China
Contacts
Public ContactQun Jin
The 960 Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army
Outcome results
None listed