Hyperuricemia
Conditions
Interventions
Lactobacillus fermentum group:Lactobacillus fermentum at a dose of 2 x 10^10 CFU, once daily, one sachet per dose (1g/sachet)
Sponsors
The Second Affiliated Hospital of Xi’an Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age 18 to 70 years, with a male proportion of no less than 30%. 2. Serum uric acid (SUA) = 480 µmol/L at screening, and SUA = 420 µmol/L at a subsequent test with an interval of at least 24 hours.
Exclusion criteria
Exclusion criteria: 1. Inability to consume oral food or comply with the prescribed intake of the study product; 2. Inability to provide clear and coherent self-reports; 3. Women who are pregnant, lactating, or planning to conceive during the study; 4. History of allergies or known hypersensitivity to the study product ingredients; 5. Diagnosed with gout or presence of tophi; 6. Gastrointestinal surgery within the past 30 days, or antibiotic treatment within the past 30 days (excluding topical or genital medications); 7. Inpatients or individuals with acute gastrointestinal diseases within the past 2 weeks; 8. Severe comorbid diseases of the heart, liver, kidney, or hematopoietic system; psychiatric disorders; patients with diabetes requiring insulin; or BMI > 35 kg/m^2; 9. Regular consumption of probiotic products within the past 30 days (more than 3 times per week), or use of medications affecting serum uric acid within the past 2 weeks (e.g., thiazide/loop diuretics, quinolones, aspirin); 10. Abnormal liver or kidney function indicators; 11. Use of urate-lowering drugs (e.g., Allopurinol, Febuxostat, Benzbromarone) within the past 3 months prior to intervention; 12. High-purine dietary habits (intake of animal viscera, seafood, or thick meat broth > 5 times per week) or habitual alcohol consumption (average daily alcohol intake > 25g); 13. Individuals deemed unsuitable for participation by the investigator; 14. Failure to sign the Informed Consent Form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum uric acid; | — |
Secondary
| Measure | Time frame |
|---|---|
| Glucose;Triglycerides;Total cholesterol;HDL-C;LDL-C;Hs-CRP;IL-6;Gut Microbiome;Allantoin; | — |
Countries
China
Contacts
Public ContactLiu Xin, Wang Qian
The Second Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed