obese asthma
Conditions
Interventions
Obesity and Asthma Group (O+A+):None
Obesity Group (O+A-):Collect normal lung tissue from 5 cm outside the lesion following lung resection
Asthma Group(O-A+):None
Non-asthmatic control group (O-A-):None
Non-asthmatic:None
Sponsors
The First Hospital Affilated to Guangzhou Traditional Chinese Medicine University
Eligibility
Sex/Gender
All
Age
15 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Diagnostic and Grouping Criteria Asthma History Group: According to the "Guidelines for the Prevention and Treatment of Bronchial Asthma (2020 Edition)", the diagnosis must be confirmed by a respiratory physician, with records of continuous medication or follow-up. Alternatively, preoperative lung function tests showing a positive bronchodilator test (FEV1 improvement >= 12% and an absolute increase >= 200 ml) qualify. Obesity Group: Body Mass Index (BMI) >= 28 kg/m^2 (China standard). Grouping: Based on the above criteria, patients are divided into four groups: (1) Obese with Asthma Group (O A): BMI >= 28 and a history of asthma. (2) Simple Obesity Group (O A-): BMI >= 28 and no history of asthma. (3) Simple Asthma Group (O-A): BMI 18.5-23.9 and a history of asthma. (4) Non-Asthma Control Group (O-A-): BMI 18.5-23.9 and no history of asthma. 2. Inclusion Criteria Case Inclusion Criteria: Patients with confirmed asthma, aged 18 years and above, with complete BMI records. Lung Tissue Sample Inclusion Criteria: (1) Aged 18-75 years, of any gender. (2) Scheduled for elective lobectomy due to clinical diagnosis (e.g., early lung cancer, bronchiectasis, pulmonary hamartoma, etc.). (3) Able to fully understand and voluntarily sign the informed consent form prior to surgery. (4) Meet the grouping criteria of one of the four groups mentioned above.
Exclusion criteria
Exclusion criteria: Case Exclusion Criteria: 1. Patients under 18 years of age; 2. Those who do not meet the inclusion criteria or have incomplete clinical data. Lung Tissue Sample Exclusion Criteria: 1. Patient or legal guardian refuses to sign the informed consent form; 2. Surgery canceled or intraoperative change of surgical procedure (e.g., only wedge resection performed); 3. Concurrent active lung diseases (e.g., active pulmonary tuberculosis, acute pneumonia, idiopathic pulmonary fibrosis, etc.); 4. Received systemic glucocorticoids, immunosuppressants, or radiotherapy/chemotherapy within 3 months before surgery (which may interfere with inflammation and molecular marker expression); 5. Pregnant or breastfeeding women; 6. Any other situations that the investigator believes may affect the execution or assessment of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VNN1 expression levels;HIF-1a expression levels; | — |
Countries
China
Contacts
Public ContactLiu huihui
The First Hospital Affilated to Guangzhou Traditional Chinese Medicine University
Outcome results
None listed