Tourniquet-Related Hypertension During Lower Limb Fracture Surgery
Conditions
Sponsors
Wuxi people’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-70 years old, gender is not limited; 2. ASA level I~III; 3.Body Mass Index (BMI) 18–24; 4.Scheduled surgery for tibial and fibular fractures or calcaneal fractures;
Exclusion criteria
Exclusion criteria: 1. Long-term oral administration of vitamin C; 2. Long-term use of glucocorticoids; 3. Allergy to ascorbic acid; 4. Pre-existing conditions including gout, uric acid nephrolithiasis, hyperoxaluria, glucose-6-phosphate dehydrogenase deficiency, hemochromatosis, sideroblastic anemia, sickle cell anemia, or thalassemia prior to surgery; 5. Pre-existing severe cardiac, hepatic, or renal dysfunction prior to surgery; 6. Exclusion criteria: (1) Voluntary withdrawal by the subject or poor compliance; (2) Application of tourniquet pressure two or more times during surgery; (3) Occurrence of serious complications during surgery, such as severe arrhythmia or hemodynamic instability.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of tourniquet-induced hypertension (TIH) during surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| QoR-15 recovery quality scores at 24 and 48 hours postoperatively;Time of first ambulation and total length of hospital stay;Visual Analogue Scale (VAS) at Rest and Ramsay Sedation Scale;Hemodynamic data;the occurrence of adverse reactions within 48 hours postoperatively;Blood gas analysis results;Intraoperative antihypertensive drug usage;Tourniquet inflation time;Opioid dosage within 48 hours postoperatively;Malondialdehyde (MDA), superoxide dismutase (SOD) activity, and total antioxidant capacity (TAC) levels in venous blood;Levels of lactate, interleukin IL-1ß, IL-8, tumor necrosis factor (TNF-a), and C-reactive protein (CRP) in venous blood;Time to spontaneous breathing, time to awakening, time to extubation, and time to orientation recovery; | — |
Countries
China
Contacts
Public ContactXin Zhang
Wuxi people’s Hospital
Outcome results
None listed