Thickened ligamentum flavum
Conditions
Interventions
Control group:None
Experimental Group:None
Sponsors
The First Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Patients who have been diagnosed with lumbar spinal stenosis (LSS) accompanied by thickening of the ligamentum flavum through imaging (MRI/CT) and clinical diagnosis; 2.During the operation, ligamentum flavum tissue is removed and sufficient specimens can be obtained for cell isolation and culture or histological detection; 3. Patients aged 40-60 years (inclusive); 4. No severe infection or systemic diseases affecting experimental results; 5. Patients are informed and have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Those with concurrent diseases such as spinal tumors, tuberculosis, and purulent infections; 2.Patients complicated with autoimmune diseases such as rheumatoid arthritis, ankylosing spondylitis and systemic lupus erythematosus; 3. Concurrent severe metabolic bone diseases (such as parathyroid dysfunction, osteomalacia, etc.) or diseases that have long-term effects on bone/ligament metabolism; 4. History of significant spinal trauma or previous lumbar surgery; 5. Long-term use of steroids, immunosuppressants, or antitumor drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| COL1A1, COL3A1, ACTA2(a-SMA);C11-BODIPY, GPX4/SLC7A11; | — |
Countries
China
Contacts
Public ContactQu Xiaochen
The First Affiliated Hospital of Dalian Medical University
Outcome results
None listed