Thyroid-associated ophthalmopathy
Conditions
Interventions
combined group:Orbital decompression with strabismus correction surgery
staged group:First undergo orbital decompression surgery, followed by strabismus correction surgery again 3–6 months postoperatively.
Sponsors
Eye Hospital, Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.A diagnosis of TAO; 2.Age >=18 years; 3.Limited eye movement secondary to TAO; 4.Stable degree of strabismus for at least 3 months prior to surgery; 5.Stable thyroid function for at least 6 months prior to surgery; 6.In an inactive phase of the disease (CAS score =3/7);
Exclusion criteria
Exclusion criteria: 1.The strabismus is caused by any other factor; 2.The presence of congenital eye diseases or developmental abnormalities that affect extraocular muscle function, such as congenital fibrosis of the extraocular muscles; 3.Previous eyelid or orbital surgery; 4.History of ocular trauma with incomplete recovery; 5.Unstable thyroid function, receipt of pulse steroid therapy, I-131 therapy, or orbital radiotherapy within the past six months; 6.TAO patients with sight-threatening conditions requiring urgent orbital surgery (optic nerve involvement,corneal ulcer); 7.Concomitant with other vision-affecting eye diseases, such as glaucoma, severe media opacities, retinal detachment, maculopathy, and optic neuropathy; 8.Presence of ocular infectious diseases, such as conjunctivitis, keratitis, endophthalmitis; 9.Uncontrolled hypertension (systolic blood pressure >180 mmHg and/or diastolic blood pressure >110 mmHg), unstable angina, recent myocardial infarction; 10.Uncontrolled diabetes mellitus (fasting blood glucose >6 mmol/L and/or glycated hemoglobin >9%); severe hepatic and renal insufficiency, abnormal liver and kidney function. 11.Active autoimmune diseases (other than TAO), such as systemic lupus erythematosus, rheumatoid arthritis; 12.Presence of coagulation disorders or current use of medications that affect coagulation function (such as warfarin, aspirin) that cannot be discontinued. 13.History of malignant tumor and currently undergoing radiotherapy or chemotherapy; 14.Other physical conditions that preclude surgical treatment, such as pregnant/lactating women, history of psychiatric disorders, history of drug addiction;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eye movement;HRCT;Vision field;Vision acuity;Synoptophore;Slit lamp and fundus lens;Stereopsis;Intraocular pressure;Exophthalmos; | — |
Secondary
| Measure | Time frame |
|---|---|
| CAS score;OCT and OCTA examination;Physical examination;ECG;GO-QoL;Severity assessment;Ocular alignment examination;Blood;Vital signs;Binocular Visual Function Test; | — |
Countries
China
Contacts
Public ContactYunhai Tu
Eye Hospital, Wenzhou Medical University
Outcome results
None listed