Insomnia
Conditions
Interventions
Healthy control group:None
The taVNS intervention group:The preferred stimulation site is the left auricle. The main site: the concha of the ear and the helix (the inner concave area of the ear). Electrode placement: Two electr
do not perform if there is any damage, inflammation, or eczema. Fix the ear clip-type electrode in the left concha area, make it fit tightly without loosening. After turning on the device, slowly incr
The tDCS intervention group:We selected the dorsolateral anterior frontal lobe on the left side as the target stimulation point. After the chronic insomnia patients completed the baseline neuro-psycho
Sponsors
the first people's hospital of hefei
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for patients with chronic insomnia (CID): 1. Age between 18 and 65 years old, with an educational level of >= 9 years (above junior high school); 2. Meeting the diagnostic criteria for CID disorder as specified in the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5); 3. PSQI score >= 7; 4. Persistent insomnia symptoms for more than three months, including difficulty falling asleep, poor sleep quality or early awakening; 5. No use of sleep medications or other psychotropic drugs within 2 weeks prior to enrollment; 6. HAMD score = 26 to exclude cognitive impairment. Inclusion criteria for healthy participants: 1. Physically healthy, without complaints of sleep disorders, emotional disorders, or cognitive impairments; 2. Normal neurological examination; 3. MMSE >= 26, HAMD <= 7; 4. Age, gender, and educational level matched with the patient group.
Exclusion criteria
Exclusion criteria: 1. History of consciousness disorders; 2. Previous history of other types of sleep disorders, such as sleep apnea, restless legs syndrome, periodic limb movement during sleep, or circadian rhythm sleep disorders (e.g., early sleep syndrome); 3. Currently using known drugs that cause insomnia (such as steroids); 4. Other medical histories: such as central nervous system infections, head injuries, epilepsy, multiple sclerosis, toxic metabolic diseases, Parkinson's disease, intracranial tumors, hypothyroidism, diabetes and other physical diseases; history of severe depression, bipolar disorder, severe anxiety disorder, schizophrenia, personality changes, etc.; 5. History of alcohol, drug, or coffee dependence; 6. Complicated with severe heart, liver, kidney, brain and hematopoietic system diseases; 7. MRI scan contraindications such as electronic and metal device implants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of sleep;Excessive arousal state;Transcranial Doppler ultrasound;Anxiety and depression score;resting-state functional MRI; | — |
Secondary
| Measure | Time frame |
|---|---|
| The Pittsburgh Sleep Quality Index (PSQI);EEG, ECG, brain color Doppler ultrasound indicators; | — |
Countries
China
Contacts
Public ContactWang Yuting
the first people's hospital of hefei
Outcome results
None listed