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A Multicenter Mixed Cohort Study on Prognostic Factors of Intentional Replantation and Autologous Tooth Transplantation

A Multicenter Mixed Cohort Study on Prognostic Factors of Intentional Replantation and Autologous Tooth Transplantation

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600125961
Enrollment
Unknown
Registered
2026-06-01
Start date
2026-06-01
Completion date
Unknown
Last updated
2026-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Refractory apical periodontitis

Interventions

Intentional Tooth Replantation Group:None
Autogenous Tooth Transplantation Group:None

Sponsors

Stomatology Hospital,Zhejiang University School Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.Age >= 18 years old, permanent dentition. 2.Meet the indications for intentional tooth replantation: refractory apical periodontitis, failed root canal treatment, and inability to undergo re-root canal therapy or apical surgery; completed root development with attachment loss less than 50%. 3.Meet the indications for autogenous tooth transplantation: dentition defect in need of restoration, suitable root morphology of donor teeth (mostly impacted third molars); sufficient bone volume at the recipient site. 4.Patients signed informed consent and were available for follow-up for at least 1 year.

Exclusion criteria

Exclusion criteria: 1.Uncontrolled systemic diseases (hypertension, diabetes mellitus, heart disease, immunosuppression, severe osteoporosis, etc.) and inability to tolerate tooth extraction. 2.Severe periodontitis, extensive alveolar bone resorption, and severe lesions of adjacent teeth. 3.Severe root resorption, root fracture, and unrestorability of the tooth. 4.Pregnancy, extremely poor compliance, and inability to complete regular follow-up. 5.Severe intraoperative complications leading to failure to complete the operation. 6.Presence of adverse factors affecting tooth prognosis, such as smoking, bruxism, malocclusion, etc.

Design outcomes

Primary

MeasureTime frame
Periodontal Probing Depth (PPD) \Clinical Attachment Loss (CAL);Apical healing status;Tooth survival rate at 1 and 2 years after treatment;

Secondary

MeasureTime frame
Visual Analogue Scale (VAS) for pain;Postoperative complications;Bone defect repair status;

Countries

China

Contacts

Public ContactDeng Shuli

Stomatology Hospital,Zhejiang University School Medicine

dengshuli3@163.com+86 571 8721 7437

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 11, 2026