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Effect of Varied Nebulization Protocols on Cough Reflex During Pulsed-Field Ablation for Atrial Fibrillation: A Prospective, Double-Blind, Randomized, Controlled Trial.

Effect of Varied Nebulization Protocols on Cough Reflex During Pulsed-Field Ablation for Atrial Fibrillation: A Prospective, Multicenter, Double-Blind, Randomized, Controlled Trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600125949
Enrollment
Unknown
Registered
2026-06-01
Start date
2026-06-01
Completion date
Unknown
Last updated
2026-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial fibrillation

Interventions

Group A:Oral Asmeton
Group B:Nebulization with salbutamol, lidocaine combined with budesonide
Group C:Oral Asmeton plus nebulization with salbutamol, lidocaine combined with budesonide

Sponsors

Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Paroxysmal atrial fibrillation 2. Age 18-80 years 3. Scheduled for catheter ablation therapy 4. ASA physical status classification I-III 5. Capable of understanding and providing written informed consent.

Exclusion criteria

Exclusion criteria: 1. Contraindications to catheter ablation (e.g., atrial thrombus) 2. Prior left atrial ablation therapy 3. History of respiratory tract infection within the past month 4. History of asthma or COPD 5. Allergy to iodine-based contrast agents 6. Concurrent participation in other drug- or device-related clinical trials 7. Pregnancy, lactation, or women of childbearing age with plans for pregnancy in the near future 8. Active infection 9. Patients who decline to participate or are unable to cooperate with the study procedures.

Design outcomes

Primary

MeasureTime frame
Cough score;

Countries

China

Contacts

Public ContactLigang Ding

Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College

dlgang101@163.com+86 88322405

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 11, 2026